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来源:休闲旅游产业热度高亲子主题酒店假期“一床难求”  作者:   发表时间:2019-11-14 10:21:56

  Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.

  MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.

  Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.

  RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”

  WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”

  AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”

  Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”

  RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.

  Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”

  WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.

  Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.

  Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.

  StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

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